Alexandre Evrard Selected Research

Pregnane X Receptor

7/2021	PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1.
1/2020	The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor.
9/2017	Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer.
1/2016	Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients.
1/2015	Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination.
3/2010	Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Alexandre Evrard Research Topics

Disease

15	Neoplasms (Cancer) 10/2020 - 03/2004
7	Breast Neoplasms (Breast Cancer) 04/2022 - 01/2017
5	Melanoma (Melanoma, Malignant) 07/2023 - 03/2003
5	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 09/2002
4	Dihydropyrimidine Dehydrogenase Deficiency 09/2018 - 08/2006
3	Neutropenia 04/2022 - 08/2006
3	Thrombocytopenia (Thrombopenia) 01/2015 - 08/2006
2	Colonic Neoplasms (Colon Cancer) 10/2013 - 03/2010
2	Squamous Cell Carcinoma of Head and Neck 12/2010 - 08/2009
1	Fever (Fevers) 07/2023
1	Oncogene Addiction 03/2023
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 03/2023
1	Prostatic Neoplasms (Prostate Cancer) 07/2021
1	Body Weight (Weight, Body) 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 11/2020
1	Papillary Thyroid Cancer 01/2020
1	Ameloblastoma 07/2019
1	Carcinoma (Carcinomatosis) 01/2019
1	Urinary Bladder Neoplasms (Bladder Cancer) 09/2017
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 09/2017
1	Renal Cell Carcinoma (Grawitz Tumor) 09/2017
1	Sepsis (Septicemia) 01/2016
1	Critical Illness (Critically Ill) 01/2016
1	Hepatocellular Carcinoma (Hepatoma) 09/2014
1	Liver Cell Adenoma (Hepatocellular Adenoma) 09/2014
1	Lymphoma (Lymphomas) 03/2012
1	Sudden Death 02/2012
1	Hand-Foot Syndrome 01/2012
1	Pre-Eclampsia (Preeclampsia) 10/2011
1	Neoplasm Metastasis (Metastasis) 12/2010
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2010

Drug/Important Bio-Agent (IBA)

8	Capecitabine (Xeloda)FDA Link 04/2018 - 09/2002
6	Pregnane X ReceptorIBA 07/2021 - 03/2010
5	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 03/2010
4	Fluorouracil (Carac)FDA LinkGeneric 09/2018 - 04/2006
3	dabrafenibIBA 07/2023 - 01/2020
3	palbociclibIBA 04/2022 - 09/2020
3	Biomarkers (Surrogate Marker)IBA 07/2021 - 08/2006
3	Gemcitabine FDA Link 10/2010 - 10/2007
3	DNA (Deoxyribonucleic Acid)IBA 04/2006 - 11/2003
3	fotemustine (Muphoran)IBA 03/2006 - 03/2003
2	Phosphotransferases (Kinase)IBA 07/2021 - 09/2020
2	Tamoxifen FDA LinkGeneric 01/2021 - 01/2019
2	Cytochrome P-450 CYP3AIBA 01/2021 - 09/2017
2	Sorafenib (BAY 43-9006)FDA Link 01/2020 - 10/2013
2	dihydrouracilIBA 04/2018 - 08/2006
2	UracilIBA 04/2018 - 08/2006
2	Carboplatin (JM8)FDA LinkGeneric 01/2015 - 10/2010
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2015 - 10/2010
2	AntimetabolitesIBA 02/2010 - 10/2007
2	Thymidine PhosphorylaseIBA 04/2006 - 03/2004
2	O-(6)-methylguanineIBA 03/2006 - 11/2003
2	MethyltransferasesIBA 03/2006 - 11/2003
2	Complementary DNA (cDNA)IBA 03/2006 - 11/2003
1	cobimetinibIBA 07/2023
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2023
1	Imatinib Mesylate (Gleevec)FDA Link 03/2023
1	Tyrosine Kinase InhibitorsIBA 03/2023
1	AfatinibIBA 07/2021
1	Dasatinib (BMS 354825)FDA Link 07/2021
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 07/2021
1	folfirinoxIBA 01/2021
1	Cytochrome P-450 CYP2C19IBA 01/2021
1	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2021
1	7-ethyl-10-hydroxycamptothecin beta-glucuronideIBA 01/2021
1	Cytochrome P-450 CYP2D6 InhibitorsIBA 01/2021
1	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Vancomycin FDA LinkGeneric 11/2020
1	ribociclibIBA 09/2020
1	VemurafenibIBA 07/2019
1	AntigensIBA 01/2019
1	EnzymesIBA 04/2018
1	temsirolimus FDA Link 09/2017
1	TOR Serine-Threonine KinasesIBA 09/2017
1	Gentamicins (Gentamicin)FDA LinkGeneric 01/2016
1	XenobioticsIBA 01/2016
1	Amikacin (A.M.K)FDA LinkGeneric 01/2016
1	LuciferasesIBA 09/2014
1	Cytarabine (Cytosar-U)FDA LinkGeneric 03/2012
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 03/2012
1	Bevacizumab (Avastin)FDA Link 02/2012
1	EndoglinIBA 10/2011
1	CholesterolIBA 10/2011
1	Etoposide (VP 16)FDA LinkGeneric 10/2010
1	Topoisomerase I InhibitorsIBA 03/2010
1	Messenger RNA (mRNA)IBA 03/2010
1	Food Additives (Food Additive)IBA 03/2010
1	Small Interfering RNA (siRNA)IBA 03/2010
1	Cytidine DeaminaseIBA 02/2010
1	tributyl phosphate (TBP)IBA 08/2009
1	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 08/2009

Therapy/Procedure

7	Drug Therapy (Chemotherapy) 01/2019 - 03/2006
5	Therapeutics 07/2023 - 09/2017
1	Castration 07/2021
1	Immunotherapy 10/2020
1	Drug Tapering 09/2018
1	Intravenous Infusions 09/2017
1	Precision Medicine 09/2017
1	Chemoradiotherapy 12/2010